0015: High LDL cholesterol decreases life expectancy in primary prevention
نویسندگان
چکیده
منابع مشابه
ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance.
Rabbits fed low-fat, cholesterol-free diets containing casein as the sole protein source develop endogenous hypercholesterolemia (EH). To test the hypothesis that lipoprotein cholesteryl esters in EH rabbits are acyl coenzyme A:cholesterol acyltransferase (ACAT) derived, we treated EH rabbits with CI-976, a potent and selective ACAT inhibitor. In addition, since cholesterol and bile acid synthe...
متن کاملPrimary disorders of LDL-cholesterol metabolism
INTRODUCTION — There are a variety of different lipid disorders that can occur as either a primary event or secondary to some underlying disease [1]. (See "Secondary causes of dyslipidemia".) The primary dyslipidemias are associated with overproduction and/or impaired removal of lipoproteins (table 1). The latter defect can be induced by an abnormality in either the lipoprotein itself or in the...
متن کاملStrengthening primordial and primary prevention of cardiovascular disease to increase life expectancy.
The article by Garcı́a González published in the Revista Española de Cardiologı́a demonstrates that life expectancy (LE) in Spain has increased by more than 6 years over the last 20 years, and that slightly more than half of this increase is due to the reduction observed in the mortality associated with cardiovascular disease (CVD). This article is important for at least 2 reasons. First, because...
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متن کاملA patient with primary biliary cirrhosis and elevated LDL cholesterol.
A 47-year-old woman was referred to us for follow-up of primary biliary cirrhosis (PBC). She reported nausea, malaise, weight loss, and new-onset jaundice. The patient had recently had an episode of melena with anemia requiring blood transfusions, but upper endoscopy and colonoscopy did not reveal a bleeding source. She reported a smoking history of 30 years and was currently smoking. The patie...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2015
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(15)71737-4